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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are typically described as focusing on practical aspects of designing a study, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and participants from different geographical regions. This kind of heterogeneity, that is crucial for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. However excessive heterogeneity could lead to problems with the design of the trial.

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The purpose of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are typically ordered by policymakers and practitioners in order to guide their decisions. They can also be a great way to identify the cause-effect relationship between an intervention and its results. They should not, however, be used to replace explanatory studies.

The pragmatism idea is controversial and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis, and pragmatic trials, which guide policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic research study that includes the recruitment, design, and 프라그마틱 슬롯 무료체험 delivery of the intervention, and follow-up.

There is an encouraging increase in the number of pragmatic trials that have been published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority were conducted in primary-care settings.