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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized by their focus on practical aspects of design which include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Pragmatic is a software development company that offers a broad range of casino games available on online gambling platforms. Pragmatic's iGaming software is used by the top operators and land based casinos. The company offers front-end tools for design, analysis, promotions, marketing payment systems, security, customer service and bug reporting. In addition, the company provides its players a secure environment with high-quality graphics and gaming.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, 프라그마틱 무료 which employed various investigators and participants from various geographical areas. This kind of heterogeneity, which is vital for pragmatic trials to be reliable and reduce bias in results is also essential. Too much heterogeneity, however, can cause problems with the design of the trial.

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Pragmatic Play is renowned for its top-notch games, and for providing a superior user experience. The software is available on mobile devices and in multiple languages. It has earned itself the status of one of the most popular casino gaming platforms despite its relatively young age. Wolves is one of its latest releases that is a 5-reel slot machine with a hefty RTP and impressive graphics. Its other notable titles are Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. Usually, they are ordered by policymakers and practitioners to help inform their decisions. They are also a good method to determine the causality between an intervention and its results. However, they shouldn't be used as a substitute for the use of explanation trials.

The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could replace explanatory tests or if they should be a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform policy and practice decision-making. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool was designed to define the characteristics of a pragmatic study which includes the recruitment process, the design and delivery of the intervention, and follow-up.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.