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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized as a focus on the practical aspects of study design that include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographical regions. This type of heterogeneity, which is essential for pragmatic trials to be valid and lessen the chance of bias, is also necessary. A high degree of heterogeneity, however, can cause problems with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically commissioned by policy makers and practitioners to guide their decision-making. They also provide a useful method of determining the causality between an intervention and its results. However, they should not, be used to replace explanatory studies.

The pragmatism idea is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials that inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study which includes recruitment, design, 프라그마틱 무료체험 메타 delivery of the intervention and its follow-up.

There is an encouraging increase in the number pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and 프라그마틱 슬롯체험 무료스핀 (sixn.net) naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.